The expansion of a continuing process for supercritical fluids is desirable for high-pressure technology. In a prior study, it had been revealed that a twin-screw extruder plastic pelletizer was applicable because the reactor and feeder for industrial supercritical fluid processes. The benefits of twin-screw extruders consist of their conveying capability and flexibility of style, which make them ideal for analysis on the applications of extruder. However, twin-screw extruders are costly because of their complicated gearbox, cylinder shape, screw, etc. In this article we report that a single-screw extruder, which is less expensive and simpler than a twin-screw extruder, can be applicable because the reactor and feeder for industrial supercritical fluid processes. Moreover, the gear for a single-screw extruder is normally smaller sized than that of a twin-screw extruder. The benefits of this study will promote the use of extruders in supercritical fluid engineering research and donate to the industrialization of a wide range of supercritical fluid techniques.