Foam Granulation part 3

china plastic machinery

A study at pilot-scale flow costs compared foamed-binder addition and direct liquid-injection on granulation. A methylcellulose binder was employed at two concentrations, 6% and 11%, in accordance with a-lactose monohydrate powder. Two screws were examined in the work to create differing axial compression qualities with changing flow rate: one with a single pair of mixing factors delivering lower axial compression and a second with two pairs in series to supply a more restrictive flow path and higher axial compression. The granule real estate from the scholarly analysis showed that similar sizes and intragranular porosity were achieved by either method, provided appropriate conditions were used. The reduced requirement for liquid along the way was a comparable finding compared to that found with high-shear batch mixers.

Wet granulation in twin screw extrusion machinery has several key positive aspects over conventional strategies, but to advance in acceptance for GMP production, its operations ought to be better understood and challenges regarding process stability should be solved. Constant foam granulation is a fresh, robust approach that solves the procedure surging problems that relate to poor powder wetting by conventional, liquid-addition methods. The high spreading tendency of foam in granulation, versus the instant soaking characteristics of liquids, produces more uniformly wetted powders and escalates the overall lubricity of the procedure, which benefits wear habit of the machine and minimizes dissipative heating system of the product. With comparable particle houses to standard wet granulation, foam granulation gives formulators higher flexibility in achieving production goals.

Write a comment

Comments: 0